Harmony Prenatal Test


Harmony Prenatal Test is a new DNA-based blood test for Down syndrome. Harmony is more accurate than traditional tests and can be performed following your 12 week scan.

As part of your antenatal care, you will be given the option to test for Down syndrome, a rare genetic condition that affects physical and mental development. Some genetic conditions run in families. Others, like Down syndrome, typically do not. They can happen in any pregnancy. Although the risk of Down syndrome increases with age, most babies with Down syndrome are born to women under 35.

What is Harmony?

When you’re pregnant, your blood contains fragments of your baby’s DNA.  Harmony Prenatal test is a new type of test that analyses this DNA in a sample of your blood to assess the risk of Down syndrome (trisomy 21) and two other genetic conditions, trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome).

For all women

Traditional screening tests can miss as many as 15% of Down syndrome cases in pregnant women.

Harmony was developed to be a more accurate prenatal Down syndrome screening test for all women, regardless of age or risk.  It is a new DNA-based blood test that has been extensively tested in pregnant women both over and under 35.

A more accurate test

Conventional screening will detect approximately 70 – 80% of pregnancies with Down syndrome.  The Harmony test will detect over 99%.  Harmony has a false positive rate of less than 0.1% compared to 5% with conventional screening.  This means that Harmony test detects more pregnancies with Down syndrome but also reduces the risk of unnecessary amniocentesis.

Clarity early

Harmony Prenatal test requires a single blood sample from your arm and can be done as early as 10 weeks or later in your pregnancy.  Results are usually available within a week.  Other commonly used tests for Down syndrome are performed later in pregnancy and require multiple clinic visits.

Minimises need for follow-up tests

The greater accuracy and low false-positive rate of Harmony compared to the traditional tests minimises the number of high risk results.  Therefore, fewer women will require follow up testing using an invasive procedure such as amniocentesis.


Your blood sample will be taken at the Michelham Unit and sent to the Harmony laboratory, where it is analysed.  Your results will be available within 3 – 5 business days from receipt of sample in the laboratory.

Test Cost: £425.00

For further information or to book an appointment please telephone 013223 413892